NMR-determined lipoprotein subclass profile predicts type 2 diabetes

Reference details

Hodge AMJ, A. J.; English, D. R.; O'Dea, K.; Giles, G. G. (2009) NMR-determined lipoprotein subclass profile predicts type 2 diabetes. Diabetes Res Clin Pract 83:132-139


AIMS: To determine whether nuclear magnetic resonance (NMR)-determined lipoprotein profiles predict type 2 diabetes. METHODS: Subjects were 813 male and female participants in the Melbourne Collaborative Cohort Study, aged 40-69 years at baseline (1990-1994), and with a baseline fasting plasma glucose <7.0 mmol/l.="" incident="" type="" 2="" diabetes="" was="" identified="" in="" 1994-1998="" by="" self-report="" and="" confirmation="" from="" doctors.="" eligible="" cases="" and="" a="" random="" group="" of="" controls="" were="" selected,="" with="" nmr="" data="" available="" for="" 59="" cases="" and="" 754="" non-cases.="" results:="" concentration="" of="" very="" low="" density="" lipoprotein="" (vldl)="" particles="" (positive)="" and="" high="" density="" lipoprotein="" (hdl)="" particle="" size="" (negative)="" were="" selected="" by="" stepwise="" regression="" as="" predictors="" of="" type="" 2="" diabetes.="" these="" associations="" were="" independent="" of="" other="" non-lipid="" risk="" factors,="" but="" not="" plasma="" triglycerides.="" factor="" analysis="" identified="" a="" factor="" from="" nmr="" variables,="" explaining="" 47%="" of="" their="" variation,="" and="" characterized="" by="" a="" positive="" correlation="" with="" vldl,="" particularly="" large="" and="" medium="" sized;="" more="" low="" density="" lipoprotein="" (ldl)="" that="" were="" smaller;="" and="" relatively="" smaller,="" but="" not="" more="" hdl="" particles.="" this="" factor="" was="" positively="" associated="" with="" diabetes="" incidence,="" but="" not="" independently="" of="" triglycerides.="" conclusions:="" we="" identified="" an="" atherogenic="" nmr="" lipoprotein="" profile="" in="" people="" who="" developed="" diabetes,="" but="" this="" did="" not="" improve="" diabetes="" prediction="" beyond="" conventional="" triglyceride="">

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