Influence of calendar period on the association between BMI and coronary heart disease: A meta-analysis of 31 cohorts

de Hollander EL, Bogers RP, Boshuizen HC, Rosengren A, Shipley MJ, Knekt P, Ducimetiere P, Menotti A, de Groot LC, Bemelmans WJ, for the BMICHDci (2012) Influence of calendar period on the association between BMI and coronary heart disease: A meta-analysis of 31 cohorts. Obesity (Silver Spring) 21:865-880

The association between obesity and coronary heart disease (CHD) may have changed over time, for example due to improved pharmacological treatment of CHD risk factors. This meta-analysis of 31 prospective cohort studies explores the influence of calendar period on CHD risk associated with body mass index (BMI). The relative risks (RRs) of CHD for a five-BMI-unit increment and BMI categories were pooled by means of random effects models. Meta-regression analysis was used to examine the influence of calendar period (>1985 v