An international case-control study of adult diet and brain tumor risk: a histology-specific analysis by food group

Terry MB, Howe G, Pogoda JM, Zhang FF, Ahlbom A, Choi W, Giles GG, Little J, Lubin F, Menegoz F, Ryan P, Schlehofer B, Preston-Martin S (2009) An international case-control study of adult diet and brain tumor risk: a histology-specific analysis by food group. Ann Epidemiol 19:161-171

PURPOSE: Existing studies of diet and adult brain tumors have been limited by small numbers in histology-specific subgroups. Dietary data from an international collaborative case-control study on adult brain tumors were used to evaluate associations between histology-specific risk and consumption of specific food groups. METHODS: The study included 1548 cases diagnosed between 1984 and 1991 and 2486 control subjects from 8 study centers in 6 countries. Of the 1548 cases, 1185 were gliomas, 332 were meningiomas, and 31 were other tumor types. Dietary consumption was measured as average grams per day. RESULTS: We found inverse associations between some vegetable groups and glioma risk, the strongest for yellow-orange vegetables (odds ratio [OR], 0.7, 95% confidence interval [CI], 0.5-0.9 for the 4th vs. 1st quartile of consumption, p for trend<0.001), and="" the="" association="" was="" limited="" to="" specific="" glioma="" subtypes.="" there="" was="" no="" association="" with="" cured="" meat.="" non-cured="" meat="" was="" associated="" with="" a="" modest="" increase="" in="" glioma="" risk="" (or,="" 1.3;="" 95%="" ci,="" 1.0-1.7="" for="" 4th="" quartile="" vs.="" 1st="" quartile,="" p="" for="" trend="0.01)." we="" also="" found="" positive="" associations="" between="" egg,="" grain,="" and="" citrus="" fruit="" consumption="" and="" glioma="" but="" not="" meningioma="" risk.="" conclusions:="" our="" study="" suggests="" that="" selected="" dietary="" food="" groups="" may="" be="" associated="" with="" adult="" gliomas="" and="" its="" subtypes="" but="" not="">