CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study

Reference details

Chang JH, Gertig DM, Chen X, Dite GS, Jenkins MA, Milne RL, Southey MC, McCredie MR, Giles GG, Chenevix-Trench G, Hopper JL, Spurdle AB (2005) CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study. Breast Cancer Res 7:R513-521

ABTRACT

INTRODUCTION: Because CYP17 can influence the degree of exposure of breast tissues to oestrogen, the interaction between polymorphisms in this gene and hormonal risk factors is of particular interest. We attempted to replicate the findings of studies assessing such interactions with the -34T-->C polymorphism. METHODS: Risk factor and CYP17 genotyping data were derived from a large Australian population-based case-control-family study of 1,284 breast cancer cases and 679 controls. Crude and adjusted odds ratio (OR) estimates and 95% confidence intervals (CIs) were calculated by unconditional logistic regression analyses. RESULTS: We found no associations between the CYP17 genotype and breast cancer overall. Premenopausal controls with A2/A2 genotype had a later age at menarche (P < 0.01).="" the="" only="" associations="" near="" statistical="" significance="" were="" that="" postmenopausal="" women="" with="" a1/a1="" (wild-type)="" genotype="" had="" an="" increased="" risk="" of="" breast="" cancer="" if="" they="" had="" ever="" used="" hormone="" replacement="" therapy="" (or="" 2.40,="" 95%="" ci="" 1.0="" to="" 5.7;="" p="0.05)" and="" if="" they="" had="" menopause="" after="" age="" 47="" years="" (or="" 2.59,="" 95%="" ci="" 1.0="" to="" 7.0;="" p="0.06)." we="" found="" no="" associations="" in="" common="" with="" any="" other="" studies,="" and="" no="" evidence="" for="" interactions.="" conclusion:="" we="" observed="" no="" evidence="" of="" effect="" modification="" of="" reproductive="" risk="" factors="" by="" cyp17="" genotype,="" although="" the="" experiment="" did="" not="" have="" sufficient="" statistical="" power="" to="" detect="" small="" main="" effects="" and="" modest="" effects="" in="" subgroups.="" associations="" found="" only="" in="" subgroup="" analyses="" based="" on="" relatively="" small="" numbers="" require="" cautious="" interpretation="" without="" confirmation="" by="" other="" studies.="" this="" emphasizes="" the="" need="" for="" replication="" in="" multiple="" and="" large="" population-based="" studies="" to="" provide="" convincing="" evidence="" for="" gene-environment="">

LinkPubMed Link

You are not logged in.