Reference details
Stoney RM, Walker KZ, Best JD, Ireland PD, Giles GG, O'Dea K (1998) Do postmenopausal women with NIDDM have a reduced capacity to deposit and conserve lower-body fat? Diabetes Care 21:828-830
ABTRACT
OBJECTIVE: To compare regional body fat distribution and sex hormone status of postmenopausal women with NIDDM with those of age- and BMI-matched normoglycemic women. RESEARCH DESIGN AND METHODS: The regional body fat distribution and sex hormone status of 42 postmenopausal women with NIDDM were compared with those of 42 normoglycemic women matched for age and BMI, who served as control subjects. Body composition was measured by dual-energy X-ray absorptiometry, and sex hormone-binding globulin (SHBG) and testosterone were measured in serum. RESULTS: Although the levels of total body fat were similar between the two groups, the women with NIDDM had significantly less lower-body fat (LBF) (P < 0.01)="" than="" the="" control="" subjects="" matched="" for="" age="" and="" bmi.="" this="" pattern="" of="" fat="" deposition="" in="" women="" with="" niddm="" was="" accompanied="" by="" an="" androgenic="" hormone="" profile,="" with="" decreased="" shbg="" concentration="" and="" an="" increased="" free="" androgen="" index="" (p="">< 0.05="" and="" p="">< 0.01,="" respectively).="" conclusions:="" a="" reduced="" capacity="" to="" deposit="" and/or="" conserve="" lbf="" may="" be="" an="" independent="" factor="" associated="" with="" (or="" may="" be="" a="" marker="" of)="" the="" metabolic="" manifestations="" of="" the="" insulin="" resistance="" syndrome="" in="" women="" with="" niddm.="" the="" possibility="" that="" the="" smaller="" relative="" accumulation="" of="" lbf="" is="" a="" consequence="" of="" the="" androgenic="" hormonal="" profile="" should="" be="" investigated="" in="" future="">
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